LY303511 (hydrochloride)

LY303511 is a close structural analog of LY294002 (Cay-70920), a selective phosphatidylinositol 3-kinase (PI3K) inhibitor. LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K. It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting casein kinase 2 activity. LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis. LY303511 is also reported to block voltage-gated potassium (Kv) channels.Formal Name: 8-phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one, dihydrochloride. CAS Number: 854127-90-5. Molecular Formula: C19H18N2O2 . 2HCl. Formula Weight: 379.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: O=C1C=C(N2CCNCC2)OC3=C1C=CC=C3C4=CC=CC=C4.Cl.Cl. InChi Code: InChI=1S/C19H18N2O2.2ClH/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14,,/h1-8,13,20H,9-12H2,2*1H. InChi Key: GUISTZFSXPSDQO-UHFFFAOYSA-N.