Lumefantrine

Lumefantrine is an antimalarial drug that is used in combination with artemether (Cay-11815). The pairing of lumefantrine and artemether is a major form of oral artemisinin combination therapy used against uncomplicated P. falciparum malaria. Lumefantrine also blocks the rapidly activating delayed-rectifier potassium channel (IKr, IC50 = 8.1 µM).Formal Name: (9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylene]-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol. CAS Number: 82186-77-4. Synonyms: Benflumetol, CPG-56695. Molecular Formula: C30H32Cl3NO. Formula Weight: 528.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml. lambdamax: 234, 265, 302, 335 nm. SMILES: OC(CN(CCCC)CCCC)C1=C(C(C=CC(Cl)=C2)=C2/C3=C/C4=CC=C(Cl)C=C4)C3=CC(Cl)=C1. InChi Code: InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-. InChi Key: DYLGFOYVTXJFJP-MYYYXRDXSA-N.