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Product information "Levobupivacaine (hydrochloride)"
Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Cay-16618). It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 µM. Levobupivacaine (10 µM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle. It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.Formal Name: 1-butyl-N-(2,6-dimethylphenyl)-(2S)-2-piperidinecarboxamide, monohydrochloride. CAS Number: 27262-48-2. Synonyms: (S)-(-)-Bupivacaine. Molecular Formula: C18H28N2O . HCl. Formula Weight: 324.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC(C=CC=C1C)=C1NC([C@H]2N(CCCC2)CCCC)=O.Cl. InChi Code: InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3,/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21),1H/t16-,/m0./s1. InChi Key: SIEYLFHKZGLBNX-NTISSMGPSA-N.
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