96 products were found matching "K04833"!

Grayanotoxin I is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey. It increases resting sodium permeability in squid axonal membranes when used at a concentration of 10 µM. Grayanotoxin I (0.25, 0.5, and 1 mg/kg) induces proteinuria and reduces serum levels of alanine...

An active metabolite of propafenone, inhibits Ito in isolated human atrial myocytes (IC50 = 1.5 µM), increases the atrial effective refractory period in dogs at 0.5, 1, and 2 mg/kg. Formulation: A solid. InChI:...

Carbamazepine (CRM) (Cay-42589) is a certified reference material categorized as a sodium channel inhibitor. Carbamazepine has been found as an adulterant in dietary supplements and heroin samples seized by law enforcement. Formulations containing carbamazepine have been used in the treatment of seizures, trigeminal...

Oxcarbazepine (CRM) (Cay-42590) is a certified reference material categorized as an anticonvulsant. Oxcarbazepine has been associated with fatal overdoses. Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures. This product is intended for analytical forensic applications. This...

Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine (Cay-20356) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent...

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...

Zonisamide is a broad-spectrum sulfonamide antiepileptic agent. It selectively blocks the repeated firing of sodium channels (IC50 = 2 µg/ml) at low concentrations in mouse embryo spinal cord neurons, and it blocks spontaneous channel firing at concentrations above 10 µg/ml. In rat cerebral cortex neurons,...

Carbamazepine-d10 is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant. It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively)....

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...

10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...

Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse...