The following products have been found matching your search "K04833": 32

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Rufinamide-15N-d2
Rufinamide-15N-d2

Item number: Cay33539-1

Rufinamide-15N-d2 is intended for use as an internal standard for the quantification of rufinamide (Cay-18870) by GC- or LC-MS. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2,...
Keywords: 1-[(2,6-difluorophenyl)methyl-d2]-1H-1,2,3-triazole-4-carboxamide-15N
Application: GC-MS, LC-MS internal standard, Quantification, Antiepileptic
CAS 1795037-48-7
MW: 241.2 D
269.00€ *
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Carbamazepine-d10
Carbamazepine-d10

Item number: Cay33486-1

Carbamazepine-d10 is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant. It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively)....
Keywords: Carbazepine-d10, 5H-dibenz[b,f]azepine-1,2,3,4,6,7,8,9,10,11-d10-5-carboxamide
Application: Internal standard, GC-MS, LC-MS, Quantification, Anticonvulsant
CAS 132183-78-9
MW: 246.3 D
From 112.00€ *
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Phenytoin-d10
Phenytoin-d10

Item number: Cay33245-1

Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin (Cay-24037) by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Cay-23889). Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium...
Keywords: 5,5-Diphenylhydantoin-d10, 5,5-di(phenyl-d5)-2,4-imidazolidinedione
Application: GC-MS, LC-MS, Internal standard, Quantification, Voltage-gated sodium channel inhibitor
CAS 65854-97-9
MW: 262.3 D
From 67.00€ *
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Levobupivacaine (hydrochloride)
Levobupivacaine (hydrochloride)

Item number: Cay31596-100

Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Cay-16618). It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 µM. Levobupivacaine (10 µM) reduces the...
Keywords: (S)-(-)-Bupivacaine, 1-butyl-N-(2,6-dimethylphenyl)-(2S)-2-piperidinecarboxamide, monohydrochloride
Application: Sodium channel blocker, Local anesthetic
CAS 27262-48-2
MW: 324.9 D
From 82.00€ *
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Oxcarbazepine
Oxcarbazepine

Item number: Cay17340-10

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...
Keywords: GP47680, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide
Application: 10-hydroxycarbazepine prodrug, Voltage-gated sodium channel blocker
CAS 28721-07-5
MW: 252.3 D
From 32.00€ *
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Rufinamide
Rufinamide

Item number: Cay18870-10

Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
Keywords: CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Application: Antiepileptic
CAS 106308-44-5
MW: 238.2 D
From 32.00€ *
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Fosphenytoin (sodium salt)
Fosphenytoin (sodium salt)

Item number: Cay23889-100

Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse...
Keywords: ACC-9653, Cl-982, 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt
Application: Voltage-gated sodium channel blocker prodrug
CAS 92134-98-0
MW: 406.2 D
From 44.00€ *
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Zonisamide
Zonisamide

Item number: Cay24183-100

Zonisamide is a broad-spectrum sulfonamide antiepileptic agent. It selectively blocks the repeated firing of sodium channels (IC50 = 2 µg/ml) at low concentrations in mouse embryo spinal cord neurons, and it blocks spontaneous channel firing at concentrations above 10 µg/ml. In rat cerebral cortex neurons,...
Keywords: CI-912, PD 110843, 1,2-benzisoxazole-3-methanesulfonamide
Application: Antiepileptic
CAS 68291-97-4
MW: 212.2 D
From 57.00€ *
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Quinidine-d3
Quinidine-d3

Item number: Cay28884-2.5

Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine (Cay-20356) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent...
Keywords: (+)-Quinidine-d3, beta-Quinidine-d3, 6'-(methoxy-d3)-cinchonan-9S-ol
Application: GC-MS, LC-MS, Internal standard, Quantification, Sodium channel blocker
CAS 1267657-68-0
MW: 327.4 D
344.00€ *
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Pirmenol
Pirmenol

Item number: Cay29042-10

Pirmenol is a class I antiarrhythmic agent. It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM. Pirmenol (2.5 and 5...
Keywords: (±)-Pirmenol, rel-alpha-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-alpha-phenyl-2-pyridinemethanol
Application: Class I antiarrhythmic agent (Ia)
CAS 68252-19-7
MW: 338.5 D
From 37.00€ *
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Pramoxine (hydrochloride)
Pramoxine (hydrochloride)

Item number: Cay30077-10

Pramoxine is a local anesthetic. It reduces electrically induced peak compound action potential (CAP) amplitudes in isolated frog sciatic nerve (IC50 = 0.21 mM). Topical administration of pramoxine (0.35 and 0.6%) inhibits winking in a rabbit corneal test, indicating anesthetic activity. It inhibits the...
Keywords: Pramocaine, 4-[3-(4-butoxyphenoxy)propyl]-morpholine, monohydrochloride
Application: Topical anesthetic
CAS 637-58-1
MW: 329.9 D
From 32.00€ *
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Mexiletine (hydrochloride)
Mexiletine (hydrochloride)

Item number: Cay23782-10

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...
Keywords: Ko 1173, 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride
Application: Sodium channel blocker
CAS 5370-01-4
MW: 215.7 D
From 32.00€ *
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