LCS3

LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR, IC50s = 3.3 and 3.8 µM, respectively). It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells. It is also active against M. tuberculosis (MIC = 0.098 µM).Formal Name: N-(4-chlorophenyl)-5-nitro-2-furancarboxamide. CAS Number: 109844-92-0. Molecular Formula: C11H7ClN2O4. Formula Weight: 266.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 251, 318 nm. SMILES: O=C(NC1=CC=C(Cl)C=C1)C=2OC(=CC2)N(=O)=O. InChi Code: InChI=1S/C11H7ClN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15). InChi Key: JDBZJNUHQINERI-UHFFFAOYSA-N.