86 products were found matching "K22182"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TXNRD1 antibody detects Thioredoxin reductase 1, a selenocysteine-containing enzyme that maintains cellular redox balance by catalyzing the NADPH-dependent reduction of thioredoxin. The UniProt recommended name is Thioredoxin reductase 1...

An inhibitor of TrxR (mean IC50 = 6.5 µM for the rat enzyme), inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 0.23 µM), inhibits IL-1beta-induced NF-kappaB DNA binding in A549 cells at 30 µM

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each...

LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR, IC50s = 3.3 and 3.8 µM, respectively). It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and...

Thioredoxin reductase 1 (TrxR1) is an oxidoreductase encoded by the TXNRD1 gene in humans and a member of the antioxidant thioredoxin system, which is involved in the maintenance of cellular thiol redox homeostasis. It exists as a homodimer and contains a dimer interface domain, FAD- and NADPH-binding domains, an...

Protein function: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. [The UniProt Consortium]

Protein function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the...

Protein function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the...

Protein function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Thioredoxin reductase 2 is also known as TRXR2, TR3, SELZ, or TR-BETA. Thioredoxin reductases, are selenocysteine (sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Thioredoxin Reductase 1 Protein function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation...