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Lacosamide selectively enhances sodium channel slow inactivation without affecting fast inactivation. It is effective in multiple rodent models of seizure activity. The neuroprotective effects of lacosamide are also attributed to its ability to modulate collapsin response mediator protein 2 (CRMP-2), a member of the semaphorin signal transduction pathway. Formulations containing lacosamide have been used as an adjunctive or monotherapy for focal-onset seizures but, at higher doses, have a low potential for abuse. Lacosamide is regulated as a Schedule V compound in the United States.Formal Name: 2R-(acetylamino)-3-methoxy-N-(phenylmethyl)-propanamide. CAS Number: 175481-36-4. Synonyms: ADD 243037, SPM 927. Molecular Formula: C13H18N2O3. Formula Weight: 250.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: COC[C@@H](NC(=O)C)C(=O)NCc1ccccc1. InChi Code: InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1. InChi Key: VPPJLAIAVCUEMN-GFCCVEGCSA-N.
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