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Prostaglandin E2 (Cay-14010) exerts its effects through four separate G-protein coupled receptors (EP1, EP2, EP3, and EP4). L-798,106 is a highly selective EP3 receptor antagonist with Ki values of 0.3, 916, >5,000, and >5,000 nM at EP3, EP4, EP1, and EP2, respectively. At 0.2 µM, it blocks the EP3 agonist activity of sulprostone (Cay-14765) on guinea pig vas deferens and trachea.Formal Name: (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide. CAS Number: 244101-02-8. Synonyms: CM 9, GW 671021. Molecular Formula: C27H22BrNO4S. Formula Weight: 536.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Acetonitrile: 1 mg/mL, DMF: 20 mg/mL, DMSO: 10 mg/mL. lambdamax: 221, 285 nm. SMILES: O=C(NS(C1=C(OC)C=CC(Br)=C1)(=O)=O)/C=C/C2=CC=CC=C2CC3=CC4=C(C=C3)C=CC=C4. InChi Code: InChI=1S/C27H22BrNO4S/c1-33-25-14-13-24(28)18-26(25)34(31,32)29-27(30)15-12-21-7-3-5-9-23(21)17-19-10-11-20-6-2-4-8-22(20)16-19/h2-16,18H,17H2,1H3,(H,29,30)/b15-12+. InChi Key: ODTKFNUPVBULRJ-NTCAYCPXSA-N.
Keywords:
CM 9, GW 671021, (2E)-N-[(5-bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide
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