L-2-Aminobutyric Acid

L-2-Aminobutyric acid is a non-proteinogenic amino acid. It inhibits LPS-induced nitric oxide (NO) production in, and reduces the bactericidal activity of, isolated mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 0.1 and 1 mM. L-2-Aminobutyric acid (75 mg/kg) increases survival in mouse models of sepsis induced by LPS or cecum ligation and puncture and decreases disease severity in a mouse model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS, Cay-23250). Serum levels of L-2-aminobutyric acid are increased in patients with COVID-19 and increased serum levels are associated with higher overall survival in patients with head and neck cancer. It has been used in the synthesis of several compounds, including the antiepileptic levetiracetam (Cay-9001820) and antimycobacterial agent ethambutol (Cay-23713).Formal Name: 2S-amino-butanoic acid. CAS Number: 1492-24-6. Synonyms: L-2-ABA, L-Butyrine, L-Homoalanine, NSC 97060. Molecular Formula: C4H9NO2. Formula Weight: 103.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC([C@H](CC)N)=O. InChi Code: InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1. InChi Key: QWCKQJZIFLGMSD-VKHMYHEASA-N.