Kumatakenin

Kumatakenin is a flavonoid that has been found in S. aromaticum and has diverse biological activities. It inhibits the growth of SKOV3 and A2780 ovarian cancer cells in a concentration-dependent manner. It induces apoptosis and decreases the protein levels of the tumor-associated macrophage (TAM) recruitment factors MCP-1 and RANTES in SKOV3 cells when used at a concentration of 30 µM. Kumatakenin (10 µM) inhibits neutrophil elastase activity and inhibits antigen-induced RBL-2H3 mast cell degranulation (IC50 = 80.4 µM). It is active against S. aureus, E. coli, P. aeruginosa, and L. monocytogenes (MICs = 64, 128, 128, and 512 µg/ml, respectively) and acts synergistically with ampicillin (Cay-14417), gentamicin, or erythromycin (Cay-16486) to reduce L. monocytogenes biofilm formation.Formal Name: 5-hydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one. CAS Number: 3301-49-3. Synonyms: Jaranol, Kaempferol 3,7-O-dimethyl ether. Molecular Formula: C17H14O6. Formula Weight: 314.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. lambdamax: 267, 350 nm. SMILES: O=C1C(OC)=C(C2=CC=C(O)C=C2)OC3=CC(OC)=CC(O)=C13. InChi Code: InChI=1S/C17H14O6/c1-21-11-7-12(19)14-13(8-11)23-16(17(22-2)15(14)20)9-3-5-10(18)6-4-9/h3-8,18-19H,1-2H3. InChi Key: BJBUTJQYZDYRMJ-UHFFFAOYSA-N. Origin: Plant/Astragalus membranaceus.