KL001

KL001 is a cryptochrome protein stabilizer. It inhibits ubiquitin-induced degradation of cryptochrome 1 (CRY1) in HEK293T cells overexpressing CRY1 when used at a concentration of 50 µM. KL001 (0.3-24 µM) lengthens the circadian period in U2OS human osteosarcoma cells in a reporter assay. It reduces glucagon-induced expression of the genes encoding phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) in primary mouse hepatocytes in a concentration-dependent manner.Formal Name: N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide. CAS Number: 309928-48-1. Molecular Formula: C21H22N2O4S. Formula Weight: 398.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 228, 235, 261, 293, 329, 343 nm. SMILES: O=S(N(CC(O)CN1C(C=CC=C2)=C2C3=C1C=CC=C3)CC4=CC=CO4)(C)=O. InChi Code: InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3. InChi Key: OQAFDLPAPSSOHY-UHFFFAOYSA-N.