KDU691

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KbetaIII and PI3Kalpha, -beta, -?, and -delta (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 µM, respectively), as well as VPS34 (IC50 = >9.7 µM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 µM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 µM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 µM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.Formal Name: N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-imidazo[1,2-a]pyrazine-6-carboxamide. CAS Number: 1513879-19-0. Molecular Formula: C22H18ClN5O2. Formula Weight: 419.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 223, 268 nm. SMILES: ClC1=CC=C(N(C)C(C(N=C2)=CN3C2=NC=C3C4=CC=C(C(NC)=O)C=C4)=O)C=C1. InChi Code: InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29). InChi Key: TYMFFISSODJRDV-UHFFFAOYSA-N.