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Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines, including the endocannabinoid arachidonoyl ethanolamide (AEA). JNJ-1661010 is a selective inhibitor of FAAH (IC50s = 34 and 33 nM in rat and human, respectively) that is able to cross the blood-brain barrier. At 20 mg/kg, JNJ-1661010 has been shown to elevate levels of AEA in rat brain. This compound has been used to examine the contribution of endocannabinoid signaling in experimental fibrosis.Formal Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. CAS Number: 681136-29-8. Molecular Formula: C19H19N5OS. Formula Weight: 365.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.5 mg/ml. lambdamax: 245 nm. SMILES: O=C(NC1=CC=CC=C1)N2CCN(C3=NC(C4=CC=CC=C4)=NS3)CC2. InChi Code: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25). InChi Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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