Isosinensetin

Isosinensetin is a polymethoxylated flavone that has been found in C. reticulata and has anticancer and anti-inflammatory activities. It inhibits P-glycoprotein (P-gp, IC50 = 4.2 µM) and increases the cytotoxicity of paraquat in MDR1-MDCKII cells and paclitaxel (Cay-10461) in MX-1 breast and paclitaxel-resistant MX-1/T cancer cells. Isosinensetin inhibits the proliferation of A549 lung, HL-60 leukemia, MCF-7 breast, and HO-8910 ovarian cancer cells (IC50s = 23.6, 23.8, 15.1, and 12.5 µM, respectively). It prevents decreases in cell viability and inhibits increases in IL-1beta, TNF-alpha, and IL-6 levels and the production of reactive oxygen species (ROS) induced by fine particulate matter less than or equal to 2.5 µm (PM2.5) in 16HBE bronchial epithelial cells when used at a concentration of 80 µg/ml.Formal Name: 2-(3,4-dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one. CAS Number: 17290-70-9. Synonyms: 6-Demethoxynobiletin. Molecular Formula: C20H20O7. Formula Weight: 372.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: soluble, Chloroform: soluble, Dichloromethane: soluble, DMSO: soluble, Ethyl Acetate: soluble. lambdamax: 248, 270, 339 nm. SMILES: O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=C1C(OC)=CC(OC)=C3OC. InChi Code: InChI=1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(24-3)10-17(25-4)19(26-5)20(18)27-14/h6-10H,1-5H3. InChi Key: UYCWETIUOAGWIL-UHFFFAOYSA-N. Origin: Plant/Citrus reticulata Blanco.