Inosine

Inosine is a purine nucleoside composed of hypoxanthine (Cay-22254) and ribose. It is formed from inosine-5'-monophosphate (Cay-18135) by 5'-nucleotidase. Inosine can also be formed by the deamination of adenosine, a post-translational modification known as A-to-I editing that occurs in tRNA and mRNA and is catalyzed by adenosine deaminase acting on RNA (ADAR). It inhibits the production of TNF-alpha, IL-1, and IL-12 in LPS-stimulated isolated mouse peritoneal macrophages when used at concentrations ranging from 30 to 1,000 µM. Inosine reduces sensorimotor impairments in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered as a continuous infusion into the cisterna magna via osmotic minipump.CAS Number: 58-63-9. Synonyms: 9-beta-D-Ribofuranosylhypoxanthine, NSC 20262. Molecular Formula: C10H12N4O5. Formula Weight: 268.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 10 mg/ml. lambdamax: 248 nm. SMILES: O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=C(C(N=CN3)=O)N=C2. InChi Code: InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1. InChi Key: UGQMRVRMYYASKQ-KQYNXXCUSA-N.