Imatinib (mesylate)

Imatinib (mesylate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13139-25 25 mg -

6 - 10 business days*

39.00€
Cay13139-50 50 mg -

6 - 10 business days*

74.00€
Cay13139-100 100 mg -

6 - 10 business days*

117.00€
Cay13139-500 500 mg -

6 - 10 business days*

505.00€
 
Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit. It... more
Product information "Imatinib (mesylate)"
Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit. It inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 µM, respectively). Imatinib inhibits the proliferation of Bcr-Abl-dependent R10(-) cells (IC50s = ~35-40 nM) and HMC-1 cells expressing constitutively active c-Kit in a concentration-dependent manner.{47196, 20180} It prolongs survival in a mouse model of chronic myeloid leukemia when administered at a dose of 100 mg/kg twice per day. Imatinib (25 and 50 µM) also inhibits the replication of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in Vero E6 cells. It reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, when used at a concentration of 10 µM via inhibition of IBV surface glycoprotein protein-induced syncytia formation and virus-cell fusion. Formulations containing imatinib have been used in the treatment of various cancers.Formal Name: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, monomethanesulfonate. CAS Number: 220127-57-1. Synonyms: CGP57148B, STI-571. Molecular Formula: C29H31N7O . CH4SO3. Formula Weight: 589.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 14 mg/ml, Ethanol: 0.2 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 238, 271 nm. SMILES: CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(C)c(c1)Nc1nccc(n1)c1cccnc1CS(=O)(=O)O. InChi Code: InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36,1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34),1H3,(H,2,3,4). InChi Key: YLMAHDNUQAMNNX-UHFFFAOYSA-N.
Keywords: CGP57148B, STI-571, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide, monomethanesulfonate
Supplier: Cayman Chemical
Supplier-Nr: 13139

Properties

Application: Tyrosine kinase inhibitor
MW: 589.7 D
Formula: C29H31N7O . CH4SO3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 220127-57-1| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H312, H341, H351, H360, H362, H373, H401, H411
P Phrases: P201, P202, P260, P263, P264, P270, P273, P280, P301+310, P302+352, P308+313, P312, P314, P321, P330, P361+364, P391, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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