Illudin M

Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It is cytotoxic to HL-60 human leukemia cells at 6-100 nM. Illudin M was used as a base structure for the development of potential anticancer agents with less toxicity and improved efficacy. It is closely related to illudin S (Cay-17451), which has been the focus of additional studies.Formal Name: (3'S,6'R)-2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one. CAS Number: 23479. Synonyms: DR-15977, (-)-Illudin M, NSC 400978, NSC 626370. Molecular Formula: C15H20O3. Formula Weight: 248.3. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: O=C1C2=CC(C)(C)[C@H](O)C2=C(C)C3(CC3)[C@]1(O)C. InChi Code: InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1. InChi Key: QVMDIQLUNODCTG-OCCSQVGLSA-N.