IKD-8344

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml). IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 µg/ml) and potentiates the activity of polymyxin B (Cay-14157) against the multidrug-resistant pathogenic bacterium B. cenocepacia. It is active against T. spiralis in vitro and in vivo.Formal Name: (1R,2R,5S,8S,9S,12R,14S,17R,18R,21S,24S,25S,28R,30S)-rel-2,9,18,25-tetramethyl-12,28-bis[(1S)-1-[(2S,5R)-tetrahydro-5-methyl-2-furanyl]ethyl]-11,27,33,34,35,36-hexaoxapentacyclo[28.2.1.15,8.114,17.121,24]hexatriacontane-3,10,19,26-tetrone. CAS Number: 129046-69-1. Molecular Formula: C48H76O12. Formula Weight: 845.1. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1O[C@]([C@@H](C)[C@]2([H])CC[C@@H](C)O2)([H])C[C@@]3([H])O[C@@](CC3)([H])[C@@H](C)C(C[C@@]4([H])O[C@](CC4)([H])[C@H](C)C(O[C@]([C@@H](C)[C@]5([H])CC[C@@H](C)O5)([H])C[C@@](CC6)([H])O[C@@]6([H])[C@@H](C)C(C[C@@](CC7)([H])O[C@]7([H])[C@@H]1C)=O)=O)=O. InChi Code: InChI=1S/C48H76O12/c1-25-9-15-41(53-25)29(5)45-23-35-13-17-39(57-35)27(3)37(49)22-34-12-20-44(56-34)32(8)48(52)60-46(30(6)42-16-10-26(2)54-42)24-36-14-18-40(58-36)28(4)38(50)21-33-11-19-43(55-33)31(7)47(51)59-45/h25-36,39-46H,9-24H2,1-8H3/t25-,26-,27+,28+,29+,30+,31+,32+,33+,34+,35+,36+,39-,40-,41+,42+,43+,44+,45-,46-/m1/s1. InChi Key: MXPYTLCDIMCGEQ-XXWADCRTSA-N. Origin: Bacterium/Spirillospora sp..