IEM 1460

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 µM-0.1 mM). It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.Formal Name: N,N,N-trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium, bromide, hydrobromide. CAS Number: 121034-89-7. Molecular Formula: C19H37N2Br . HBr. Formula Weight: 454.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: C[N+](C)(C)CCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.[Br-]. InChi Code: InChI=1S/C19H37N2.2BrH/c1-21(2,3)8-6-4-5-7-20-15-19-12-16-9-17(13-19)11-18(10-16)14-19,,/h16-18,20H,4-15H2,1-3H3,2*1H/q+1,,/p-1/t16-,17+,18-,19?,,. InChi Key: CQTDZUSQSTUZDA-VUKQHJSDSA-M.