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Iberin is a natural isothiocyanate found in cruciferous plants. When introduced into the daily diet of rats or added to rat hepatocytes (40 µM), it induces the expression of phase II detoxification enzymes, including quinone reductase and glutathione S-transferase. In addition, iberin activates the nuclear factor E2-related protein Nrf2, which promotes the expression of antioxidant and phase II genes. Iberin also induces the apoptosis of some cancer cell lines. Interestingly, iberin also acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth (IC50 = 31-62 µM).Formal Name: 1-isothiocyanato-3-(methylsulfinyl)-propane. CAS Number: 505-44-2. Synonyms: NSC 321801. Molecular Formula: C5H9NOS2. Formula Weight: 163.3. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 16 mg/ml, DMSO: 16 mg/ml, Ethanol: 11 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 246 nm. SMILES: CS(CCCN=C=S)=O. InChi Code: InChI=1S/C5H9NOS2/c1-9(7)4-2-3-6-5-8/h2-4H2,1H3. InChi Key: LELAOEBVZLPXAZ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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