Hydroxyurea (Carbamohydroxamic acid, Carbamoyl oxime, N-Carbamoylhydroxylamine)

Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Synonyms: Carbamohydroxamic acid, N-Carbamoylhydroxylamine, N-Hydroxyurea, Biosupressin, Carbamohydroxamic Acid, Carbamoyl Oxime, Cytodrox, Droxia, HU, Hidrix, Hydrea, Hydreia, Hydroxycarbamide, Hydroxycarbamine, N-(Aminocarbonyl)hydroxylamine, Hydroxylurea, Hydura, Hydurea, Litaler, Litalir, N-Carbamoylhydroxylamine, NCI C04831, NSC 32065, Oxyurea, SK 22591, SQ 1089, CAS Number: 127-07-1, Molecular Formula: CH4N2O2, Molecular Weight: 76.06, Appearance: White to off-white crystalline powder, Purity: 97.0%-103%, Solubility: Soluble in water, practically insoluble in alcohol, soluble in hot alcohol. Identification (IR): Passes USP, Loss on Drying: <0.5%, Residue of Ignition: <0.1%, Heavy Metals (Pb): <0.002%, Melting Point: 138-145°C, Related Substances: <0.2%, Urea: <0.5%, Chloride: <0.005%, Storage and Stability: May be stored at 4°C. Stable for 12 months after receipt. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.