HPI-1 (hydrate)

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 > 30 µM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.Formal Name: 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid-2-methoxyethyl ester, hydrate. Molecular Formula: C27H29NO6 . XH2O. Formula Weight: 463.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 3 mg/ml, Ethanol: 20 mg/ml. SMILES: COC1=CC=CC=C1C2CC(NC(C)=C(C(OCCOC)=O)C3C4=CC(O)=CC=C4)=C3C(C2)=O.O. InChi Code: InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20-9-4-5-10-23(20)33-3,/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3,1H2. InChi Key: BOASXIAGFOONSK-UHFFFAOYSA-N.