HLY78

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. HLY78 is a positive modulator of the Wnt/beta-catenin pathway, as it augments Wnt-mediated signaling in cells at concentrations of 5 to 20 µM. It has no significant effect alone, and it does not affect LiCl-stimulated beta-catenin signaling. A biotinylated form of HLY78 binds Axin at its DIX domain, which is thought to potentiate Axin-LRP6 association. HLY78 activates Wnt signaling in vivo, altering Wnt-dependent gene expression and embryonic development in zebrafish.Formal Name: 4-ethyl-5,6-dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine. CAS Number: 854847-61-3. Molecular Formula: C17H17NO2. Formula Weight: 267.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml, DMSO: 2 mg/ml, Ethanol: 2 mg/ml. lambdamax: 214, 282, 319 nm. SMILES: CCC1=CC=CC2=C1N(C)CC3=CC4=C(OCO4)C=C32. InChi Code: InChI=1S/C17H17NO2/c1-3-11-5-4-6-13-14-8-16-15(19-10-20-16)7-12(14)9-18(2)17(11)13/h4-8H,3,9-10H2,1-2H3. InChi Key: FAZZYPIBZBGQSH-UHFFFAOYSA-N.