GYY 4137

Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 production and reducing NF-kappaB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.Formal Name: (p-methoxyphenyl)morpholino-phosphinodithioic acid. CAS Number: 106740-09-4. Molecular Formula: C11H16NO2PS2 . C4H10NO. Formula Weight: 377.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: COc1ccc(cc1)P(=S)([S-])N1CCOCC1.C1COCC[NH2+]1. InChi Code: InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12,1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17),5H,1-4H2. InChi Key: YZMHNNLDUWRZFW-UHFFFAOYSA-N.