GW 9508

GW 9508 is a small-molecule agonist of GPR40/FFA1 (EC50 = 47.8 nM for calcium mobilization in HEK293 cells). It is selective for GPR40/FFA1 over GPR120/FFA4 (EC50 = 3,467 nM), as well as GPR43/FFA2 and GPR41/FFA3 (EC50s = >50 µM). GW 9508 potentiates glucose-stimulated and potassium chloride-mediated insulin secretion in MIN6 pancreatic beta-cells but does not affect glucose-stimulated insulin secretion in primary rat or mouse islet cells. It increases phosphorylation of AMP-activated protein kinase (AMPK) and acyl-CoA carboxylase (ACC), indicating AMPK and ACC activation, and decreases hepatic lipid accumulation in a mouse model of high-cholesterol diet-induced hepatic steatosis when administered at a dose of 100 mg/kg per day for three days.Formal Name: 4-[[(3-phenoxyphenyl)methyl]amino]-benzenepropanoic acid. CAS Number: 885101-89-3. Molecular Formula: C22H21NO3. Formula Weight: 347.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml, Methanol: 30 mg/ml. lambdamax: 245, 297 nm. SMILES: OC(=O)CCc1ccc(cc1)NCc1cccc(c1)Oc1ccccc1. InChi Code: InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25). InChi Key: DGENZVKCTGIDRZ-UHFFFAOYSA-N.