GSK650394

GSK650394 is an inhibitor of serum- and glucocorticoid-regulated kinase (IC50s = 62 and 103 nM for SGK1 and SGK2, respectively). It demonstrates greater than 30-fold selectivity for SGK1 over Akt and other related kinases. GSK650394 can inhibit the androgen-stimulated growth of human prostate carcinoma LNCaP cells with an IC50 value of ~ 1 µM.Formal Name: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid. CAS Number: 890842-28-1. Molecular Formula: C25H22N2O2. Formula Weight: 382.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 241, 257, 295 nm. SMILES: O=C(O)C(C(C1CCCC1)=C2)=CC=C2C3=CNC4=NC=C(C5=CC=CC=C5)C=C43. InChi Code: InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29). InChi Key: WVSBGSNVCDAMCF-UHFFFAOYSA-N.