GSK3484862

GSK3484862 is an inhibitor of DNA methyltransferase 1 (DNMT1, IC50 = 0.23 µM). It is selective for DNMT1 over DNMT3A/3L and DNMT3B/3L (IC50s = >50 µM for both). GSK3484862 (100-1,000 nM) inhibits the growth of MV4-11 leukemia cells. It also decreases promoter DNA methylation in MV4-11 cells.Formal Name: alphaR-[[3,5-dicyano-6-(dimethylamino)-4-ethyl-2-pyridinyl]thio]-benzeneacetamide. CAS Number: 2170136-65-7. Molecular Formula: C19H19N5OS. Formula Weight: 365.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 270, 304, 347 nm. SMILES: NC([C@@H](C1=CC=CC=C1)SC2=C(C#N)C(CC)=C(C#N)C(N(C)C)=N2)=O. InChi Code: InChI=1S/C19H19N5OS/c1-4-13-14(10-20)18(24(2)3)23-19(15(13)11-21)26-16(17(22)25)12-8-6-5-7-9-12/h5-9,16H,4H2,1-3H3,(H2,22,25)/t16-/m1/s1. InChi Key: KIEQQZZDWUNUQK-MRXNPFEDSA-N.