GPP 78

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.Formal Name: N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-1H-1,2,3-triazole-1-octanamide. CAS Number: 1202580-59-3. Synonyms: CAY10618, NMPRTase Inhibitor. Molecular Formula: C27H29N5O. Formula Weight: 439.6. Purity: >95%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 234 nm. SMILES: O=C(NC1=C(C2=CC=CC=C2)C=CC=C1)CCCCCCCN3N=NC(C4=CC=CN=C4)=C3. InChi Code: InChI=1S/C27H29N5O/c33-27(29-25-16-9-8-15-24(25)22-12-5-4-6-13-22)17-7-2-1-3-10-19-32-21-26(30-31-32)23-14-11-18-28-20-23/h4-6,8-9,11-16,18,20-21H,1-3,7,10,17,19H2,(H,29,33). InChi Key: SJOLTIOPWDLDEB-UHFFFAOYSA-N.