GNF-2
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Larger quantity required? Request bulk
GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive,... more
Product information "GNF-2"
GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive, and anti-osteoporotic activities. GNF-2 shows potential benefit in the treatment of Philadelphia chromosome-positive acute myelogenous leukemia (ALL). In vitro, GNF-2 inhibits differentiation of osteoclasts, activity of NF-kappaB, and induction of c-Fos and NFATc1, resulting in caspase-mediated apoptosis. GNF-2 also inhibits resorption of mature osteoclasts and prevents phagocytosis in bone marrow-derived macrophages. In vivo, this compound decreases osteoclast numbers and prevents bone loss.
| Supplier: | LKT Laboratories |
| Supplier-Nr: | G5320 |
Properties
| Application: | Bcr-abl inhibitor |
| MW: | 374.32 D |
| Formula: | C18H13F3N4O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 778270-11-4| Matching products |
| KEGG ID : | K06619 | Matching products |
Handling & Safety
| Storage: | +20°C |
| Shipping: | +20°C (International: °C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P332+313, P337+313, P362+364, P403, P233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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