GNF-2

GNF-2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16253-1 1 mg -

6 - 10 business days*

125.00€
Cay16253-5 5 mg -

6 - 10 business days*

216.00€
Cay16253-10 10 mg -

6 - 10 business days*

308.00€
Cay16253-50 50 mg -

6 - 10 business days*

854.00€
 
GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM). It is selective for Bcr-Abl over... more
Product information "GNF-2"
GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion. It inhibits LPS-induced production of nitric oxide (NO) and TNF-alpha in BV-2 microglia when used at concentrations of 10 and 20 µM. GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund's adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ, Cay-13104).Formal Name: 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide. CAS Number: 778270-11-4. Synonyms: Bcr-Abl Inhibitor. Molecular Formula: C18H13F3N4O2. Formula Weight: 374.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 268 nm. SMILES: NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O. InChi Code: InChI=1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25). InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N.
Keywords: Bcr-Abl Inhibitor, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 16253

Properties

Application: Bcr-abl inhibitor
MW: 374.3 D
Formula: C18H13F3N4O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 778270-11-4| Matching products
KEGG ID : K06619 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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