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Gallein is an inhibitor of G protein betagamma subunit-dependent signaling. It binds to Gbeta1gamma2 in a cell-free assay (IC50 = 200 nM) and inhibits Gbetagamma-dependent activation of PI3K in HL-60 cells. Gallein (10 µM) also inhibits Rac1 activation, superoxide production, and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP, Cay-21495) in differentiated HL-60 cells. In vivo, gallein (10 mg/kg per day) increases survival, reduces ventricular hypertrophy, and attenuates cardiac remodeling in a mouse model of heart failure induced by transverse aortic constriction (TAC).Formal Name: 3',4',5',6'-tetrahydroxy-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one. CAS Number: 2103-64-2. Synonyms: C.I. 45445, NSC 56445, NSC 8668, NSC 622478, Pyrogallol phthalein. Molecular Formula: C20H12O7. Formula Weight: 364.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): slightly soluble. lambdamax: 227 nm. SMILES: OC1=C(O)C2=C(C=C1)C3(C(C=CC=C4)=C4C(O3)=O)C5=CC=C(O)C(O)=C5O2. InChi Code: InChI=1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H. InChi Key: PHLYOKFVXIVOJC-UHFFFAOYSA-N.
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