Forodesine (hydrochloride)

Forodesine is a purine nucleoside derivative and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs, IC50s = 9002864). Forodesine inhibits the proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).Formal Name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, dihydrochloride. Molecular Formula: C11H14N4O4 . 2HCl. Formula Weight: 339.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 230 nm. SMILES: O=C1C2=C(C([C@H]3[C@H](O)[C@H](O)[C@@H](CO)N3)=CN2)NC=N1.Cl.Cl. InChi Code: InChI=1S/C11H14N4O4.2ClH/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19,,/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19),2*1H/t5-,7+,9-,10+,,/m1../s1. InChi Key: BKBYUXDMYPGLTQ-PUSSMWDMSA-N.