FMK

FMK is an inhibitor of p90 ribosomal S6 kinase 3alpha (RSK2, IC50 = 15 nM). It inhibits the C-terminal domain (CTD) kinase activity of RSK2 and inhibits EGF-induced phosphorylation of RSK2 Ser386 in serum-starved COS-7 cells (EC50 = ~200 nM). FMK (6 µM) reduces invasion, but not proliferation, of M4e, 212LN, and 37B human head and neck squamous cell carcinoma cells. It also inhibits FGFR3-induced growth of Ba/F3 cells in a concentration-dependent manner and induces apoptosis in OPM-1, LP-1, and KMS-18 human myeloma cells expressing the t(4,14) translocation mutation and FGFR3 when used at a concentration of 10 µM.Formal Name: 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-ethanone. CAS Number: 821794-92-7. Synonyms: Fluoromethyl Ketone, Fluoromethyl Ketone-MEA, FMK-MEA. Molecular Formula: C18H19FN4O2. Formula Weight: 342.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. lambdamax: 233, 331 nm. SMILES: FCC(C1=C(C2=CC=C(C)C=C2)C(C(N)=NC=N3)=C3N1CCCO)=O. InChi Code: InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22). InChi Key: IKLGYJACVCXYIL-UHFFFAOYSA-N.