Ethopropazine (hydrochloride)

Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 µM in human erythrocyte lysates). It is selective for BChE over acetylcholinesterase (AChE) at 500 µM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively. Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 (Cay-20447). It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg. Formulations containing ethopropazine were previously used in the treatment of Parkinson's disease.Formal Name: N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethanamine, monohydrochloride. CAS Number: 1094-08-2. Synonyms: NSC 64074, NSC 169467. Molecular Formula: C19H24N2S . HCl. Formula Weight: 348.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:5): 0.16mg/mL, DMSO: 5mg/mL, Ethanol: 5mg/mL. lambdamax: 252 nm. SMILES: CC(N(CC)CC)CN1C2=C(C=CC=C2)SC3=CC=CC=C31.Cl. InChi Code: InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21,/h6-13,15H,4-5,14H2,1-3H3,1H. InChi Key: VXPCQISYVPFYRK-UHFFFAOYSA-N.