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ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG, IC50 = 315 nM). It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells (HUVECs), which do not express ERG (IC50s = >10 µM for all). ERGi-USU (100 and 150 mg/kg) reduces tumor growth in a VCaP mouse xenograft model.Formal Name: 1-[2-(2-thiazolyl)diazenyl]-2-naphthalenol. CAS Number: 1147-56-4. Synonyms: NSC 139021. Molecular Formula: C13H9N3OS. Formula Weight: 255.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMSO: 5mg/mL, Ethanol: 0.5mg/mL. lambdamax: 213, 226, 482 nm. SMILES: OC1=C(/N=N/C2=NC=CS2)C(C=CC=C3)=C3C=C1. InChi Code: InChI=1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H/b16-15+. InChi Key: IOMXCGDXEUDZAK-FOCLMDBBSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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