Elemicin

Elemicin is a trioxygenated phenylpropane that has been found in A. dracunculus. It is active against S. aureus, B. subtilis, and C. albicans (MICs = 600, 2,500, and 1,000 mg/L, respectively) but not E. coli, K. pneumoniae, P. aeruginosa (MICs = >8,000 mg/L for all), or L. monocytogenes (MIC = >3,000 mg/L). Elemicin is toxic to mice following metabolic activation to 1'-hydroxyelemicin by the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. It increases plasma and hepatic triglyceride levels, decreases stearoyl-CoA desaturase 1 (Scd1) expression, and induces hepatomegaly in mice when administered at a dose of 500 mg/kg per day for three weeks.Formal Name: 1,2,3-trimethoxy-5-(2-propen-1-yl)-benzene. CAS Number: 487-11-6. Synonyms: NSC 16704. Molecular Formula: C12H16O3. Formula Weight: 208.3. Purity: >98%. Formulation: (Request formulation change), A liquid. Solubility: DMF: 30mg/mL, DMSO: 15mg/mL, Ethanol: 20mg/mL. SMILES: COC1=CC(CC=C)=CC(OC)=C1OC. InChi Code: InChI=1S/C12H16O3/c1-5-6-9-7-10(13-2)12(15-4)11(8-9)14-3/h5,7-8H,1,6H2,2-4H3. InChi Key: BPLQKQKXWHCZSS-UHFFFAOYSA-N. Origin: Synthetic.