Efonidipine

Efonidipine is an inhibitor of L- and T-type voltage-gated calcium channels (Cavs). It inhibits Cav1.2a (IC50 = 1.8 nM for the hamster channel), an L-type Cav, and Cav3.2 (IC50 = 350 nM for the human channel), a T-type Cav. It also inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes. Efonidipine (200 mg/kg) increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery. Efonidipine is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro, IC50 = 38.5 µM).Formal Name: 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-[phenyl(phenylmethyl)amino]ethyl ester. CAS Number: 111011-63-3. Synonyms: (±)-Efonidipine. Molecular Formula: C34H38N3O7P. Formula Weight: 631.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml. lambdamax: 250 nm. SMILES: O=C(C1=C(C)NC(C)=C(P2(OCC(C)(CO2)C)=O)C1C3=CC([N+]([O-])=O)=CC=C3)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5. InChi Code: InChI=1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45/h5-17,20,31,35H,18-19,21-23H2,1-4H3. InChi Key: NSVFSAJIGAJDMR-UHFFFAOYSA-N.