Dronedarone-d6 (hydrochloride)

Dronedarone-d6 is intended for use as an internal standard for the quantification of dronedarone (Cay-9000543) by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Cay-15213). It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol (carbamoylcholine, Cay-14486) or intracellular loading of GTPgammaS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively). Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing. Formulations containing dronedarone have been used in the treatment of atrial fibrillation.Formal Name: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy-1,1,2,2,3,3-d6]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride. CAS Number: 1329809-23-5. Molecular Formula: C31H38D6N2O5S . HCl. Formula Weight: 599.3. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: CCCCC1=C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C=C2)=O)C3=CC(NS(C)(=O)=O)=CC=C3O1.Cl. InChi Code: InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3,/h13-18,23,32H,5-12,19-22H2,1-4H3,1H/i11D2,21D2,22D2,. InChi Key: DWKVCQXJYURSIQ-RADSTHBLSA-N.