Dorzolamide (hydrochloride)

Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM. It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 µM, respectively). Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%. It also reduces intraocular pressure in an alpha-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%. Formulations containing dorzolamide have been used in the treatment of glaucoma.Formal Name: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide, 7,7-dioxide, monohydrochloride. CAS Number: 130693-82-2. Synonyms: L-671,152, MK-507. Molecular Formula: C10H16N2O4S3 . HCl. Formula Weight: 360.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. lambdamax: 255 nm. SMILES: O=S1([C@@H](C)C[C@H](NCC)C2=C1SC(S(N)(=O)=O)=C2)=O.Cl. InChi Code: InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16,/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16),1H/t6-,8-,/m0./s1. InChi Key: OSRUSFPMRGDLAG-QMGYSKNISA-N.