Doramectin

Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. At 0.001 µg/ml, doramectin is fully effective at inhibiting growth in an H. contortus larval development assay.Formal Name: 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-avermectin A1a. CAS Number: 117704-25-3. Synonyms: Cyclohexylavermectin B1, UK 67994. Molecular Formula: C50H74O14. Formula Weight: 899.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Soluble, Methanol: Soluble, Water: Miscible. lambdamax: 245 nm. SMILES: C/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(C=C[C@H](C)[C@@H](C8CCCCC8)O7)O6. InChi Code: InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,2. InChi Key: QLFZZSKTJWDQOS-YDBLARSUSA-N.