Doramapimod

The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFalpha release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM. At 10 µM, doramapimod inhibits JNK2alpha2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.Formal Name: N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-urea. CAS Number: 285983-48-4. Synonyms: BIRB-796. Molecular Formula: C31H37N5O3. Formula Weight: 527.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 3 mg/ml. lambdamax: 211, 238, 303 nm. SMILES: O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=CC=C(OCCN4CCOCC4)C5=C3C=CC=C5. InChi Code: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37). InChi Key: MVCOAUNKQVWQHZ-UHFFFAOYSA-N.