Dodecyl Gallate

Dodecyl gallate is a derivative of the antioxidant gallic acid (Cay-11846) that has diverse biological activities, including antioxidant, antiproliferative, and antibacterial properties. It inhibits proliferation of a variety of cancer cells, including WEHI-231 mouse B cell lymphoma, Daudi human lymphoma, and HT-29 human colon cancer cells (IC50s = 0.8, 1.4, and 17.0 µM, respectively). It induces apoptosis of WEHI-231 cells but not L-929 mouse fibroblasts. Dodecyl gallate decreases peroxidation of ox brain phospholipid liposomes by 71 and 76% when used at concentrations of 12 and 50 µM, respectively, and scavenges trichloromethyl peroxyl radicals at 0.05% w/v. It is active against a variety of Gram-positive bacteria, including B. subtilis (MIC = 25 µg/ml), as well as M. luteus, S. aureus, and methicillin-resistant S. aureus (MRSA, MICs = 12.5 µg/ml for all), and acts by inhibiting the bacterial membrane respiratory chain.Formal Name: 3,4,5-trihydroxy-benzoic acid, dodecyl ester. CAS Number: 1166-52-5. Synonyms: Gallic Acid dodecyl ester, Gallic Acid lauryl ester, Lauryl Gallate, NSC 133463. Molecular Formula: C19H30O5. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 220, 276 nm. SMILES: O=C(C1=CC(O)=C(C(O)=C1)O)OCCCCCCCCCCCC. InChi Code: InChI=1S/C19H30O5/c1-2-3-4-5-6-7-8-9-10-11-12-24-19(23)15-13-16(20)18(22)17(21)14-15/h13-14,20-22H,2-12H2,1H3. InChi Key: RPWFJAMTCNSJKK-UHFFFAOYSA-N.