Demethoxycurcumin

Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 µM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/beta-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.Formal Name: 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1E,6E-heptadiene-3,5-dione. CAS Number: 22608-11-3. Synonyms: DMC. Molecular Formula: C20H18O5. Formula Weight: 338.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 254, 421 nm. SMILES: OC1=CC=C(/C=C/C(CC(/C=C/C2=CC(OC)=C(O)C=C2)=O)=O)C=C1. InChi Code: InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+. InChi Key: HJTVQHVGMGKONQ-LUZURFALSA-N.