Dehydro Amlodipine (fumarate)

Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine. It is a degradation product formed during storage or when amlodipine (Cay-14838) is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation.Formal Name: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester, 2-butenedioate. CAS Number: 2138811-33-1. Molecular Formula: C20H23ClN2O5 . C4H4O4. Formula Weight: 522.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml. SMILES: CC1=NC(COCCN)=C(C(OCC)=O)C(C2=C(Cl)C=CC=C2)=C1C(OC)=O.OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/C20H23ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21,5-3(6)1-2-4(7)8/h5-8H,4,9-11,22H2,1-3H3,1-2H,(H,5,6)(H,7,8)/b,2-1+. InChi Key: BWAQLJHPVPAANJ-WLHGVMLRSA-N.