Darifenacin-d4

Darifenacin-d4 is intended for use as an internal standard for the quantification of darifenacin (Cay-14424) by GC- or LC-MS. Darifenacin is an antagonist of M3 muscarinic acetylcholine receptors (mAChRs, Ki = 0.76 nM). It is selective for M3 over M1, M2, M4, and M5 mAChRs (Kis = 7.08, 44.67, 45.71, and 9.33 nM, respectively). Darifenacin selectively inhibits contractions in isolated guinea pig ileum, bladder, and trachea (pA2s = 9.44, 8.66, and 8.7, respectively), tissues that endogenously express high levels of M3 mAChRs, over isolated rabbit vas deferens and isolated guinea pig atria (pA2s = 7.9 and 7.48, respectively), which endogenously express M1 and M2 mAChRs, respectively. It inhibits micturition pressure (ED50 = 0.089 mg/kg, i.v.), as well as micturition interval and volume in rats. Formulations containing darifenacin have been used in the treatment of overactive bladder.Formal Name: 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl-1,1,2,2-d4]-alpha,alpha-diphenyl-3-pyrrolidineacetamide. CAS Number: 1189701-43-6. Molecular Formula: C28H26D4N2O2. Formula Weight: 430.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble. SMILES: NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3CN(C([2H])([2H])C([2H])([2H])C4=CC=C(OCC5)C5=C4)CC3)=O. InChi Code: InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/i13D2,16D2. InChi Key: HXGBXQDTNZMWGS-MIMPEXOTSA-N.