DA-3003-2

Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. Through the removal of inhibitory phosphates, they function to catalyze the activation of cyclin-Cdk complexes. DA-3003-2 is a Cdc25 phosphatase inhibitor (IC50 = 0.82 µM for human recombinant Cdc25B) that demonstrates antiproliferative activity. At 20 µM, it has been shown to arrest asynchronous PC-3 prostate cancer cells in G2/M phase.Formal Name: 7-chloro-6-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione. CAS Number: 383907-47-9. Synonyms: NSC 663285. Molecular Formula: C15H16ClN3O3. Formula Weight: 321.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml. lambdamax: 233, 272, 477 nm. SMILES: O=C(C(NCCN1CCOCC1)=C2Cl)C3=C(N=CC=C3)C2=O. InChi Code: InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)14(20)10-2-1-3-17-12(10)15(11)21/h1-3,18H,4-9H2. InChi Key: LGTBDMBBPVNDSZ-UHFFFAOYSA-N.