D609 (potassium salt)

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC, Ki = 6.4 µM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC50 = 20 µg/ml) and IL-1beta-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.Formal Name: O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt. CAS Number: 83373-60-8. Synonyms: Tricyclodecan-9-yl xanthogenate. Molecular Formula: C11H15OS2 . K. Formula Weight: 266.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.3 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 231, 304 nm. SMILES: [S-]C(OC1CC2C(CCC3)C3C1C2)=S.[K+]. InChi Code: InChI=1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8,/h6-10H,1-5H2,(H,13,14),/q,+1/p-1. InChi Key: IGULCCCBGBDZKQ-UHFFFAOYSA-M.