D-myo-Inositol-4,5-diphosphate (sodium salt)

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a key second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to one of several Ins(1,4,5)P3 receptors results in opening of the calcium channels and an increase in intracellular calcium. Ins(4,5)P2 is a metabolite of Ins(1,4,5)P3 that lacks a phosphate at the 1' position. Ins(4,5)P2 formation has been reported as an intermediate in the metabolism Ins(1,4,5)P3 in GH3 pituitary cells.Formal Name: D-myo-inositol-4,5-di(hydrogen phosphate), disodium salt. Synonyms: Ins(4,5)-P2 (sodium salt), 4,5-IP2 (sodium salt). Molecular Formula: C6H12O12P2 . 2Na. Formula Weight: 384.1. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 50 mg/ml. SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1O.[Na+].[Na+]. InChi Code: InChI=1S/C6H14O12P2.2Na/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13,,/h1-10H,(H2,11,12,13)(H2,14,15,16),,/q,2*+1/p-2/t1-,2+,3-,4-,5?,6?,,/m0../s1. InChi Key: AGYHIHUTKCMLKM-GFRJWRMMSA-L.