Cyproheptadine-d3

Cyproheptadine-d3 is intended for use as an internal standard for the quantification of cyproheptadine (Cay-19551) by GC- or LC-MS. Cyproheptadine is an antihistamine with antiserotonergic and anticholinergic activities. It binds to histamine H1, muscarinic, and serotonin 5-HT2 receptors (Kis = 0.38, 1.26, and 0.83 nM, respectively, in radioligand binding assays). Cyproheptadine reduces histamine-induced spasms in isolated guinea pig ileum (IC75 = 0.0014 µg/ml). It protects against intravenous histamine diphosphate-induced death with a 50% protective dose (PD50) value of 0.08 mg/kg and delays induction of aerosolized histamine diphosphate-induced coughing (ED100sec = 0.29 mg/kg) in guinea pigs. Cyproheptadine also inhibits the lysine methyltransferase SET7/9 (IC50 = 1 µM), decreasing the expression of estrogen receptor alpha (ERalpha) in MCF-7 cells. Formulations containing cyproheptadine have been used in the treatment of allergic reactions including rhinitis, conjunctivitis, and urticaria.Formal Name: 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-(methyl-d3)-piperidine. CAS Number: 2712455-05-3. Molecular Formula: C21H18D3N. Formula Weight: 290.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: [2H]C([2H])([2H])N(CC/1)CCC1=C2C(C=CC=C3)=C3C=CC4=C\2C=CC=C4. InChi Code: InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3/i1D3. InChi Key: JJCFRYNCJDLXIK-FIBGUPNXSA-N.