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Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P4 couples to Galphai, Galphao, and Galpha12/13 proteins leading to the stimulation of MAPK/ERK signaling pathways, as well as to PLC and Rho-Cdc42 activation, and is thought to contribute to immune responses. CYM 50308 is a novel agonist of S1P4 (EC50 = 56 nM) that displays 37-fold selectivity against S1P5 (EC50 = 2.1 µM) and no appreciable activity over the S1P1-3 subtypes at concentrations up to 25 µM.Formal Name: (2Z,5Z)-5-[[1-(2,4-difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone. CAS Number: 1345858-76-5. Synonyms: CID-49835928, ML-248. Molecular Formula: C20H21F2N3O2S. Formula Weight: 405.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml. lambdamax: 363 nm. SMILES: FC1=CC(F)=C(N2C(C)=CC(/C=C3S/C(N(C)C\3=O)=N\CCOC)=C2C)C=C1. InChi Code: InChI=1S/C20H21F2N3O2S/c1-12-9-14(13(2)25(12)17-6-5-15(21)11-16(17)22)10-18-19(26)24(3)20(28-18)23-7-8-27-4/h5-6,9-11H,7-8H2,1-4H3/b18-10-,23-20-. InChi Key: BKQZKTRCUAWRHT-ZGNGNRKCSA-N.
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